Long Distance Relationship: While close to the Defender, the attacker gains a Weakness Debuff every 3 seconds, reducing their attack by 10% permanently. Staying away from the Defender causes these weakness effects to gradually fall off.
When you stay close to the defender, you get a weakness Debuff. Your playstyle should be focused on making sure you remove the weakness, or the fight takes a lot longer than necessary.
Do:
Bring Tenacity or Purify or Cleanse champions, if you can remove the Debuff that makes the fights very easy.
Bring people who reduce Ability Accuracy, this node can be stopped by Ability Accuracy Reduction, but OML is immune so that won’t work on him.
Bring Parry/Heavy champs.
Bring people like, Doctor Doom or Iron Man, who’s specials create distance.
Use the Willpower mastery.
Don't:
Don’t bring Mystics that struggle with non-damaging Debuffs. Example: Juggernaut.
Don’t bring Champs who require to stay close to the opponent. Example: Omega Red, or Quake.
Don’t bring Champs with long combos. Example: Black Cat, Quicksilver.
OML -> Vision -> Magneto -> Ant man -> Juggernaut -> Mordo -> Scarlet Witch -> Ghost (Boss)
GHOST (Boss): As you can probably tell after doing a few fights, this quest is very easy. For this boss, all you need is someone who doesn’t care about Limber, i.e. someone who intercepts easily, e.g. Hercules, or just bring one of the Magnetos. If you don’t have these Champs, don’t worry, this fight is very easy just try to intercept.
This is by far the easiest node in 6.1. All you need to do is not do anything silly against Mordo or Ghost and this should be an itemless quest.