Close Encounters: While close to the Defender the Attacker Regenerates 1% of their Max Health every second. While far away from the defender, the attacker takes Direct Damage equal to 3% of their Mac Health every second.
Stay as close to the defender as possible for as long as possible.
Do:
Bring Champs who require to stay close to the opponent. Examples: Omega Red, or Quake.
Bring Champs with long combos. Examples: Black Cat, Quicksilver.
Bring Champs with Degen immunity.
Bring Champs who can temporarily ignore damage. Kitty Pryde (Awakened), Champs with Indestructible, Ghost with Hood synergy.
Don't:
Don’t bring Parry/Heavy champs.
Don’t bring Champs like Doctor Doom or CGR, Champs with Specials create distance.
Path: Phoenix –> Sabretooth –> Wolverine –> Guillotine –> The Hood -> Loki (Boss)
Loki (Boss): This quest is very easy once you understand the nodes. For the fights, the key thing to understand is how to punish their Special Attacks as quickly as possible. For Loki, it’s not possible to punish the specials unless you use Tigra, however anyone works for this fight as long as they don’t have too many buffs.
This is by far the easiest node in 6.1. All you need to do is not do anything silly against Mordo or Ghost and this should be an itemless quest.