Main Nodes:

------------ All Path Fights -----------

Punishment Glutton: Gain fury each time a damaging debuff expires/purified from defender.
Rapid Metabolism: They shrug off debuffs 40% faster

------------Fights 1 - 3-----------

Trial by Fire: If you don't hit the Defender within 6 seconds you get an Incinerate for 6 seconds. (This Node ends after Fight 3)

------------Fights 4 - 9 ----------

Tranquility: Every 20 seconds all Buffs, Debuffs and Power are removed from both Champs. (This Node ends after Fight 9)

------------Fights 10 - 15--------

Spiritualism: Your Power Gain Rate is reduced by 90%. Launch your Stryker to gain 45% of your Max Power.
Free Spirited: Your Spirit Gain is increased to 200%

Path Fights in Order:

OG Thor | Thor Rags | Immortal Abom | Omega Sentinel | Silk | Venompool | Hyperion | Gwenpool | Carnage | Superior Iron Man | Captain Marvel (Movie) | Mysterio | Drax | Green Goblin | Hela
No revives used

Landmine Fights:

Immortal Abom could be a pain- bring a Poison Immune (Hawkeye or Yelena) or someone that shrugs (like Kingpin).

Omega Sentinel I used Elsa to give me easy openings. But her Auto-Block hurts, I took a lot of Block Damage here.

Strategy Drop: Use Nick Fury about halfway through and hold onto his SP3. Get them close to death and let them take you to Real Nick Fury and drop the SP3 to KO them- you start the next Fight at full health!

Quest Boss: Doom (Mystic)

Main Nodes:

Pulling Rank - 7-Stars: 7-Star attackers gain a permanent Attack Bonus based on their rank ranging from +800 to +2,800
Buff Toggle (Unstoppable): He gets an Unstoppable every 9 seconds. Lasts for 3 seconds.
Critical Shock Tether: If either of you have not made contact within 8 seconds you get a Critical Shock Passive for 3 seconds.
Enhanced parry - Power gain: When you Parry you get a Power Gain Buff for 5 seconds. Does not stack.
Buffet Over Time: When you trigger a Buff, its immediately Nullified and he gets a Regen Buff for 7 seconds. This has a 7 second cooldown.
Immune Cycle (Slow/Heal Block/Stun): He goes immune to those one at a time. Rotates every 10 seconds.

Old Sarge Says:

Thing is a safe but very slow option for this fight. He is immune to Shock and immune to Nullify. And he goes unstoppable a lot which helps if you forget about the Buff Toggle Unstoppable node- Plus Thing nullifies Unstoppable for 8 seconds after his Special Attacks. For some reason I wasn't getting the Fury Passive when Rock Stacks above 15 expired/were removed- not sure why.

Civilian Intel:

Cheelith is great for him too,She cleanses shock and easy counter to unstoppable Spam Sp1, hold to launch sp1 little before that unstoppable kicks. My 7R2 managed with just 40% health loss.
I went again and with Photon- he was dead within a minute and without a scratch hardly 20% damage to her. She is 7R3.
- - She is best as doom is spamming heavy and she goes untouchable which in result gives me window to attack if not unstoppable. She counter his annoying heavy, regen and powergain and the best his resistance to crit with her heavy. So is best IMO.
Count Nefaria destroys doom. Cheese
Spider-Ham (NOTE: Some users are saying DO NOT use Ham)